Публикации и достижения центра

  1. Bragina, O., von Witting, E., Garousi, J., Zelchan, R., Sandström, M., Orlova, A., Medvedeva, A., Doroshenko, A., Vorobyeva, A., Lindbo, S., Borin, J., Tarabanovskaya, N., Sörensen, J., Hober, S., Chernov, V., & Tolmachev, V. Phase I Study of 99mTc-ADAPT6, a Scaffold Protein-Based Probe for Visualization of HER2 Expression in Breast Cancer //Journal of nuclear medicine. – 2021. – Vol. 62. – No. 4. – P. 493–499.
    DOI:10.2967/jnumed.120.248799
    https://jnm.snmjournals.org/content/62/4/493
  2. Bragina, O., Chernov, V., Schulga, A., Konovalova, E., Garbukov, E., Vorobyeva, A., Orlova, A., Tashireva, L., Sorensen, J., Zelchan, R., Medvedeva, A., Deyev, S., & Tolmachev, V. Phase I trial of 99mTc-(HE)3-G3, a DARPin-based probe for imaging of HER2 expression in breast cancer //Journal of nuclear medicine: official publication, Society of Nuclear Medicine.– 2021. – jnumed.121.262542. Advance online publication. 
    DOI:10.2967/jnumed.121.262542
    https://jnm.snmjournals.org/content/early/2021/08/12/jnumed.121.262542
  3. Tano, H., Oroujeni, M., Vorobyeva, A., Westerlund, K., Liu, Y., Xu, T., Vasconcelos, D., Orlova, A., Karlström, A.E., Tolmachev, V. Comparative Evaluation of Novel 177Lu-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting //Cancers. – 2021. – Vol. 13. – No. 3. – P. 500. 
    DOI: 10.3390/cancers13030500  
    https://www.mdpi.com/2072-6694/13/3/500
  4. Garousi, J., von Witting, E., Borin, J., Vorobyeva, A., Altai, M., Vorontsova, O., Konijnenberg, M.W., Oroujeni, M., Orlova, A., Tolmachev, V.  Hober, S. Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle //Biomaterials. – 2021. – Vol. 266. – P. 120381
    DOI:10.1016/j.biomaterials.2020.120381
    https://www.sciencedirect.com/science/article/pii/S014296122030627X
  5. Oroujeni, M., Rinne, S.S., Vorobyeva, A., Loftenius, A., Feldwisch, J., Jonasson, P., Chernov, V., Orlova, A., Frejd, F.Y., Tolmachev, V. Preclinical Evaluation of 99mTc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake //International Journal of Molecular Sciences. – 2021. – Vol. 22. –  No. 2770.
    DOI:10.3390/ijms22052770 
    https://www.mdpi.com/1422-0067/22/5/2770
  6. Abouzayed, A., Rinne, S. S., Sabahnoo, H., Sörensen, J., Chernov, V., Tolmachev, V., Orlova, A. Preclinical Evaluation of 99mTc-Labeled GRPR Antagonists maSSS/SES-PEG2-RM26 for Imaging of Prostate Cancer //Pharmaceutics. – 2021. – Vol. 13. – No. 2. – P. 182.
    DOI: 10.3390/pharmaceutics13020182  
    https://www.mdpi.com/1999-4923/13/2/182
  7. Oroujeni, M., Xu, T., Gagnon, K., Rinne, S.S., Weis, J., Garousi, J., Andersson, K.G., Löfblom, J., Orlova, A. and Tolmachev, V. Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule  //Pharmaceutics. – 2021. – Vol. 13. –  No. 292.
    DOI: 10.3390/pharmaceutics13020292 
    https://www.mdpi.com/1999-4923/13/2/292
  8. Rinne, S.S.; Leitao, C.D.; Abouzayed, A.; Vorobyeva, A.; Tolmachev, V.; Ståhl, S.; Löfblom, J.; Orlova, A. HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers. Cancers. – 2021. – Vol. 13.– P. 4791.
    DOI:10.3390/cancers13194791
    https://www.mdpi.com/2072-6694/13/19/4791
  9. Xu, T., Vorobyeva, A., Schulga, A., Konovalova, E., Vorontsova, O., Ding, H., Gräslund, T., Tashireva, L. A., Orlova, A., Tolmachev, V., & Deyev, S. M. Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model //Cancers.– 2021. – Vol. 13. – No. 16. – P. 3939. 
    DOI:10.3390/cancers13163939
    https://www.mdpi.com/2072-6694/13/16/3939
  10. Deyev, S. M., Xu, T., Liu, Y., Schulga, A., Konovalova, E., Garousi, J., Rinne, S. S., Larkina, M., Ding, H., Gräslund, T., Orlova, A., Tolmachev, V., & Vorobyeva, A. Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1 //Cancers.– 2021. – Vol. 13. – No. 14. – P. 3589. 
    DOI:10.3390/cancers13143589
    https://www.mdpi.com/2072-6694/13/14/3589
  11. Liu, Y., Vorobyeva, A., Xu, T., Orlova, A., Loftenius, A., Bengtsson, T., Jonasson, P., Tolmachev, V., & Frejd, F. Y. Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody® Molecules 177Lu-ABY-271 and 177Lu-ABY-027: Impact of DOTA Position on ABD Domain  //Pharmaceutics.– 2021. – Vol. 13. – No. 6. – P. 839. 
    DOI:10.3390/pharmaceutics1306083
    https://pubmed.ncbi.nlm.nih.gov/34200197
  12. Rinne, S. S., Orlova, A., & Tolmachev, V. PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology //International journal of molecular sciences. – 2021. – Vol. 22. – No. 7. – P. 3663.
    DOI: 10.3390/ijms22073663
    https://www.mdpi.com/1422-0067/22/7/3663
  13. Rinne, S.S., Abouzayed, A., Gagnon, K., Tolmachev, V., Orlova, A. 66 Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66 Ga] Ga-NOTA-PEG 2-RM26 //Scientific reports. – 2021. – Vol. 11. – No. 1. – P. 1-12. 
    DOI: 10.1038/s41598-021-82995-7
    https://pubmed.ncbi.nlm.nih.gov/33574368
  14. Oroujeni, M., Xu, T., Gagnon, K., Rinne, S.S., Weis, J., Garousi, J., Andersson, K.G., Löfblom, J., Orlova, A. and Tolmachev, V. Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule  //Pharmaceutics. – 2021. – Vol. 13. –  No. 292.
    DOI: 10.3390/pharmaceutics13020292 
    https://www.mdpi.com/1999-4923/13/2/292
  15. Abouzayed, A., Rinne, S. S., Sabahnoo, H., Sörensen, J., Chernov, V., Tolmachev, V., Orlova, A. Preclinical Evaluation of 99mTc-Labeled GRPR Antagonists maSSS/SES-PEG2-RM26 for Imaging of Prostate Cancer //Pharmaceutics. – 2021. – Vol. 13. – No. 2. – P. 182.
    DOI: 10.3390/pharmaceutics13020182  
    https://www.mdpi.com/1999-4923/13/2/182
  16. Oroujeni, M., Rinne, S.S., Vorobyeva, A., Loftenius, A., Feldwisch, J., Jonasson, P., Chernov, V., Orlova, A., Frejd, F.Y., Tolmachev, V. Preclinical Evaluation of 99mTc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake //International Journal of Molecular Sciences. – 2021. – Vol. 22. –  No. 2770.
    DOI:10.3390/ijms22052770 
    https://www.mdpi.com/1422-0067/22/5/277
  17. Garousi, J., von Witting, E., Borin, J., Vorobyeva, A., Altai, M., Vorontsova, O., Konijnenberg, M.W., Oroujeni, M., Orlova, A., Tolmachev, V.  Hober, S. Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle //Biomaterials. – 2021. – Vol. 266. – P. 120381
    DOI:10.1016/j.biomaterials.2020.120381
    https://www.sciencedirect.com/science/article/pii/S014296122030627X
  18. Xu, T., Ding, H., Vorobyeva, A., Oroujeni, M., Orlova, A., Tolmachev, V., Graslung, T. Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model //Cancers. – 2021. – Vol. 13. – No. 85. – P. 1-21.
    DOI: 10.3390/cansers13010085  
    https://www.mdpi.com/2072-6694/13/1/85
  19. Tano, H., Oroujeni, M., Vorobyeva, A., Westerlund, K., Liu, Y., Xu, T., Vasconcelos, D., Orlova, A., Karlström, A.E., Tolmachev, V. Comparative Evaluation of Novel 177Lu-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting //Cancers. – 2021. – Vol. 13. – No. 3. – P. 500. 
    DOI: 10.3390/cancers13030500  
    https://www.mdpi.com/2072-6694/13/3/500
  20. Tolmachev, V., Orlova, A., & Sörensen, J. The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer //Seminars in Cancer Biology. – Academic Press, 2021.   
    DOI: 10.1016/j.semcancer.2020.10.005 
     https://www.sciencedirect.com/science/article/pii/S1044579X20302108
  21. Ding, H., Xu, T.,  Zhang, J., Tolmachev, V., Oroujeni, M., Orlova, A., Gräslund, T., Vorobyeva, A. Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution //Pharmaceutics. – 2021. – Vol. 13. –  No. 430.
    DOI: 10.3390/pharmaceutics13030430.
    https://www.mdpi.com/search?q=Affibody-Derived+Drug+&journal=pharmaceutics
  22. Zelepukin, I.V., Popov, A.A., Shipunova, V.O., Tikhonowski, G.V., Mirkasymov, A.B., Popova-Kuznetsova, E.A., Klimentov, S.M., Kabashin, A.V.,  Deyev, S.M. Laser-synthesized TiN nanoparticles for biomedical applications: evaluation of safety, biodistribution and pharmacokinetics  //Materials Science and Engineering: C. – 2021. – Vol. 120.  – P. 111717.
    DOI:10.1016/j.msec.2020.111717 
    https://www.sciencedirect.com/science/article/pii/S0928493120336365
  1. Dudnikova Y.A., Chernov V.I., Muravleva A.V., Kravchuk T.L., Zelchan R.V., Medvedeva A.A., Bragina O.D., Simolina Y.L., Popova N.O., Vysockaja V.V., Lukina N.M., Shatalova V.A., Shpileva O.V., Goldberg A.V., Goldberg V.Y. Metabolic single-photon emission computed tomography with the new radiopharmceutical 99Tc-1-thio-D-glucose in the diagnosis and monitoring of the primary breast lymphoma (case report) //Siberian journal of oncology. – 2020. – Vol. 19. – No.5. – P. 145-153.
    DOI: 10.21294/1814-4861-2020-19-5-145-153 
    https://www.siboncoj.ru/jour/article/view/1589
  2. Dudnikova Y.A., Chernov V.I., Muravleva A.V., Kravchuk T.L., Zelchan R.V., Medvedeva A.A., Bragina O.D., Simolina Y.L., Popova N.O., Vysockaja V.V., Lukina N.M., Shatalova V.A., Shpileva O.V., Goldberg A.V., Goldberg V.Y. Metabolic single-photon emission computed tomography with the new radiopharmceutical 99Tc-1-thio-D-glucose in the diagnosis and monitoring of the primary breast lymphoma (case report) //Siberian journal of oncology. – 2020. – Vol. 19. – No.5. – P. 145-153.Vorobyeva, A., 
    DOI: 10.21294/1814-4861-2020-19-5-145-153
    https://www.siboncoj.ru/jour/article/view/1589?locale=en_US
  3. Vorobyeva, A., Bezverkhniaia, E., Konovalova, E., Schulga, A., Garousi, J., Vorontsova, O., Abouzayed, A., Orlova, A., Deyev, S., Tolmachev, V. Radionuclide molecular imaging of EpCAM expression in triple-negative breast cancer using the scaffold protein DARPin Ec1 //Molecules. – 2020. – Vol. 25. – No. 20. – P. 4719.
    DOI: 10.3390/molecules25204719
    https://www.mdpi.com/1420-3049/25/20/4719
  4. Bezverkhniaia, E.A., Povet’eva, T.N., Kadyrova, T.V., Suslov, N.I., Nesterova, Y.V., Ol’ga, G., Kul’pin, P.V., Yusova, Y.G., Ermilova, E.V., Miroshnichenko, A.G., Brazovskii, K.S. Screening study for anticonvulsive activity of lipophilic fractions from empetrum nigrum L. //Research Results in Pharmacology. – 2020. – Vol. 6.  – P.67
    DOI: 10.3897/rrpharmacology.6.55015
    https://cyberleninka.ru/article/n/screening-study-for-anticonvulsive-activity-of-lipophilic-fractions-from-empetrum-nigrum-l/viewer
  5. Shramova, E. I., Kotlyar, A. B., Lebedenko, E. N., Deyev, S. M., Proshkina, G. M. Near-Infrared Activated Cyanine Dyes As Agents for Photothermal Therapy and Diagnosis of Tumors.//Acta Nature. – 2020. – Vol. 12. – No. 3(46). – P. 102-113.
    DOI: 10.32607/actanaturae.11028 
    http://actanaturae.ru/2075-8251/article/view/11028
  6. Lundmark, F., Abouzayed, A., Mitran, B., Rinne, S.S., Varasteh, Z., Larhed, M., Tolmachev, V., Rosenström, U., Orlova, A. Heterodimeric radiotracer targeting PSMA and GRPR for imaging of prostate cancer—optimization of the affinity towards PSMA by linker modification in murine model //Pharmaceutics. – 2020. – Vol. 12. – No. 7. – P. 614.
    DOI: 10.3390/pharmaceutics12070614
    https://www.mdpi.com/1999-4923/12/7/614
  7. Shramova, E., Proshkina, G., Shipunova, V., Ryabova, A., Kamyshinsky, R., Konevega, A., Schulga, A., Konovalova, E., Telegin, G., Deyev, S. Dual targeting of cancer cells with darpin-based toxins for overcoming tumor escape //Cancers. – 2020. – Vol. 12. – No. 10. – P. 3014.
    DOI:10.3390/cancers12103014 
    https://www.mdpi.com/2072-6694/12/10/3014
  8. Mitran B., Tolmachev V., Orlova A. Radiolabeled grpr antagonists for imaging of disseminated prostate cancer. Influence of labeling chemistry on targeting properties //Current medicinal chemistry. – 2020. – Vol. 27. – No. 41. – P. 7090-7111.
    DOI: 10.2174/0929867327666200312114902 
    https://www.ingentaconnect.com/content/ben/cmc/2020/00000027/00000041/art00013;jsessionid=1v764c8qjxtbk.x-ic-live-01
  9. Garousi, J., Vorobyeva, A. and Altai, M., 2020. Influence of Several Compounds and Drugs on the Renal Uptake of Radiolabeled Affibody Molecules //Molecules. – 2020. – Vol. 25. – No. 11. – P. 2673.
    DOI: 10.3390/molecules25112673  
    https://www.mdpi.com/1420-3049/25/11/2673
  10. Vorobyeva, A., Oroujeni, M., Lindbo, S., Hober, S., Xu, T., Liu, Y., Rinne, S.S. and Garousi, J., 2020. Investigation of a pharmacological approach for reduction of renal uptake of radiolabeled adapt scaffold protein //Molecules. – 2020. – Vol. 25. – No. 19. – P. 4448.
    DOI:10.3390/molecules25194448
    https://www.mdpi.com/1420-3049/25/19/4448
  11. Trofimova, E.S., Zykova, M.V., Sherstoboev, E.Y., Danilets, M.G., Ligacheva, A.A. and Belousov, M.V. Effects of Humic Acids, Isolated from High-Moor Pine-Peat Moss-Cotton Grass Peat on the Production of Cytokines by Mouse and Human Immunocompetent Cells and on Humoral Immune Response // Bulletin of experimental biology and medicine. – 2020. – Vol. 168. – No. 5. – P. 651-653.
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    https://search.proquest.com/openview/2692d43b9f3d023a5faf9ed38ab29aea/1?cbl=47742&pq-origsite=gscholar
  12. Guler, R., Svedmark, S. F., Abouzayed, A., Orlova, A., & Lofblom, J. Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches //Scientific reports. – 2020. – Vol. 10. – No. 1. – P. 1-14.
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    https://www.nature.com/articles/s41598-020-74560-5
  13. Baun, C., Mitran, B., Rinne, S. S., Dam, J. H., Olsen, B. B., Tolmachev, V., Orlova, A. Thisgaard, H. Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer //Molecules. 2020. – Vol. 25. – No. 24. – P. 5993.
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    https://www.mdpi.com/1420-3049/25/24/5993
  14. Myrhammar, A., Vorobyeva, A., Westerlund, K., Yoneoka, S., Orlova, A., Tsukahara, T.,  & Altai, M. Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting //Scientific Reports. – 2020. – Vol. 10. – No. 1. – P. 1-12.
    DOI: 10.1038/s41598-020-77523-y
    https://www.nature.com/articles/s41598-020-77523-y
  15. Abouzayed, A., Tano, H., Nagy, A., Rinne, S.S., Wadeea, F., Kumar, S., Westerlund, K., Tolmachev, V., Karlstrom, A.E., Orlova, A. Preclinical evaluation of the grpr-targeting antagonist rm26 conjugated to the albumin-binding domain for grpr-targeting therapy of cancer // Pharmaceutics. – 2020. – Vol. 12. – No. 10. – P. 977.
    DOI: 10.3390/pharmaceutics12100977
    https://www.mdpi.com/1999-4923/12/10/977
  16. Leitao, C.D., Rinne, S.S., Altai, M., Vorontsova, O., Dunas, F., Jonasson, P., Tolmachev, V., Lofblom, J., Stahl, S., Orlova, A. Evaluating the therapeutic efficacy of mono-and bivalent affibody-based fusion proteins targeting HER3 in a pancreatic cancer xenograft model //Pharmaceutics. – 2020. – Vol. 12. – No. 6. – P. 551.
    DOI: 10.3390/pharmaceutics12060551
    https://www.mdpi.com/1999-4923/12/6/551
  17. Ding, H., Altai, M., Yin, W., Lindbo, S., Liu, H., Garousi, J., Xu, T., Orlova, A., Tolmachev, V., Hober, S., Graslund, T. HER2-specific pseudomonas exotoxin a pe25 based fusions: Influence of targeting domain on target binding, toxicity, and in vivo biodistribution //Pharmaceutics. – 2020. – Vol. 12. – No. 4. – P. 391.
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  18. Tolmachev, V., Orlova, A. Affibody molecules as targeting vectors for PET imaging //Cancers. – 2020. – Vol. 12. – No. 3. – P. 651.
    DOI: 10.3390/cancers12030651
    https://www.mdpi.com/2072-6694/12/3/651
  19. Rinne, S.S., Leitao, C.D., Saleh-Nihad, Z., Mitran, B., Tolmachev, V., Stahl, S., Lofblom, J., Orlova, A. Benefit of later-time-point PET imaging of her3 expression using optimized radiocobalt-labeled affibody molecules //International journal of molecular sciences. – 2020. – Vol. 21. – No. 6. – P. 1972.
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    https://www.mdpi.com/1422-0067/21/6/1972
  20. Deyev, S.M., Vorobyeva, A., Schulga, A., Abouzayed, A., Gunther, T., Garousi, J., Konovalova, E., Ding, H., Graslund, T., Orlova, A., Tolmachev, V. Effect of a radiolabel biochemical nature on tumor-targeting properties of EpCAM-binding engineered scaffold protein DARPin Ec1 //International Journal of Biological Macromolecules. – 2020. – Vol. 145. – P. 216-225.
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    https://www.sciencedirect.com/science/article/pii/S0141813019393808
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  22. Altai, M., Vorobyeva, A., Tolmachev, V., Karlstrom, A.E., Westerlund, K. Preparation of Conjugates for Affibody-Based PNA-Mediated Pretargeting //Peptide Nucleic Acids. – Humana, New York, NY, 2020. – P. 283-304.
    DOI: 10.1007/978-1-0716-0243-0_18
  23. Bragina, O.D., Vorobyeva, A.G., Tolmachev, V.M., Orlova, A.M., Chernov, V.I., Deyev, S.M., Proshkina, G.N., Shulga, A.A., Larkina, M.S., Medvedeva, A.A., Zelchan, R.V. In vitro and in vivo evaluation of the radiochemical compound based on 99m technetium labelled DARPin9_29 for molecular visualization of malignancies overexpressing Her2/neu [In vitro и in vivo оценка радиохимического соединения на основе меченного 99m-Tc каркасного белка  DARPin9_29 для молекулярной визуализации злокачественных образований с гиперэкспрессией Her2/neu] //Medical Radiology and Radiation Safety. – 2020. – Vol. 65. – No. 1. – P. 37-41.
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  24. Vorobyeva, A., Konovalova, E., Xu, T., Schulga, A., Altai, M., Garousi, J., Rinne, S.S., Orlova, A., Tolmachev, V., Deyev, S. Feasibility of imaging epcam expression in ovarian cancer using radiolabeled darpin ec1 //International Journal of Molecular Sciences. – 2020. – Vol. 21. – No. 9. – P. 3310.
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  25. Larkina, M.S., Ozerskaya, A.V., Podrezova, E.V., Belousov, M.V., Tolmachev, V., Zhdankin, V.V., Yusubov, M.S. Efficient Synthesis of w-[18F]Fluoroaliphatic Carboxylic Esters and Acids for Positron Emission Tomography //European Journal of Organic Chemistry. – 2020. – Vol. 2020. – No. 40. – P. 6375-6381.
    DOI: 10.1002/ejoc.202000934
    https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202000934
  26. Alhuseinalkhudhur, A., Lubberink, M., Lindman, H., Tolmachev, V., Frejd, F.Y., Feldwisch, J., Velikyan, I., Sörensen, J. Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer //EJNMMI research. – 2020. – Vol. 10. – No. 1. – P. 1-10.
    DOI: 10.1186/s13550-020-0603-9
    https://ejnmmires.springeropen.com/articles/10.1186/s13550-020-0603-9
  1. Lar’kina, M.S., Krivoshchekov, S.V., Podrezova, E.V., Bragina, O.D., Chernov, V.I., Nesterov, E.A., Bodenko, V.V., Belousov, M.V., Yusubov, M.S. Validation of an Analytical HPLC Method for a New Diagnostic Octreotide Derivative for Neuroendocrine Tumors //Pharmaceutical Chemistry Journal. – 2019. – Vol. 53. – No. 9. – P. 865-870.
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